Thursday, March 13, 2014
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neutrophil-targeting nanoparticles to prevent inflammation-induced tissue
nanoparticles could help prevent tissue damage involving vascular
inflammation. In mice with vascular inflammation, bovine serum albumin
nanoparticles were preferentially internalized by neutrophils adhering to the
inflammation site. In these mice, albumin nanoparticles loaded with the spleen tyrosine kinase (SYK)
decreased Syk pathway-induced vascular adhesion of neutrophils compared with
unloaded nanoparticles. In mouse models of acute lung injury, piceatannol-loaded
nanoparticles decreased neutrophil infiltration and lung inflammation
compared with free piceatannol. Next steps include testing nanoparticles
loaded with SYK inhibitors or other classes of neutrophil adhesion inhibitors
in models of acute lung injury, sepsis and/or ischemia/reperfusion injury.
Gilead Sciences Inc.
an oral SYK inhibitor, in Phase II trials to treat hematological
Rigel Pharmaceuticals Inc.
an oral SYK inhibitor, in Phase II testing to treat idiopathic
thrombocytopenic purpura (ITP).
ZaBeCor Pharmaceutical Co.
an siRNA targeting SYK, in Phase II testing to treat asthma.
Published online March 13, 2014
Patented by the University of Illinois; available
Wang, Z. et al. Nat.
Nanotechnol.; published online Feb. 23, 2014;
Contact: Asrar B. Malik, University of Illinois at Chicago
College of Medicine, Chicago, Ill.
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