Thursday, March 13, 2014
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Assays & screens
Protein M, an IgG-binding
protein with a new mode of antibody interaction
In vitro studies suggest Protein M, a broadly reactive,
antibody-binding protein, could complement Proteins A and G as a reagent for
large-scale antibody purification. Protein M from Mycoplasma genitalium
bound all isotypes of human and nonhuman IgG through a binding mode distinct
from other high-affinity IgG-binding proteins targeting a conserved region on
the variable chain of IgG. In binding assays, pretreatment with recombinant
Protein M blocked binding between antibody-antigen pairs including a
monoclonal anti-influenza antibody-antigen pair and a mouse polyclonal lupus
antibody-antigen pair. Ongoing studies could include purifying the agent for
therapeutic and research purposes.
Published online March 13, 2014
Patent application filed;
licensing negotiations under way with three undisclosed companies; available
Grover, R.K. et al.
Science; published online Feb. 7, 2014;
Contact: Richard A. Lerner, The Scripps Research Institute, La
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