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Assays & screens

Protein M, an IgG-binding protein with a new mode of antibody interaction

In vitro studies suggest Protein M, a broadly reactive, antibody-binding protein, could complement Proteins A and G as a reagent for large-scale antibody purification. Protein M from Mycoplasma genitalium bound all isotypes of human and nonhuman IgG through a binding mode distinct from other high-affinity IgG-binding proteins targeting a conserved region on the variable chain of IgG. In binding assays, pretreatment with recombinant Protein M blocked binding between antibody-antigen pairs including a monoclonal anti-influenza antibody-antigen pair and a mouse polyclonal lupus antibody-antigen pair. Ongoing studies could include purifying the agent for therapeutic and research purposes.

SciBX 7(10); doi:10.1038/scibx.2014.294
Published online March 13, 2014

Patent application filed; licensing negotiations under way with three undisclosed companies; available for licensing

Grover, R.K. et al. Science; published online Feb. 7, 2014;
Contact: Richard A. Lerner, The Scripps Research Institute, La Jolla, Calif.