Thursday, March 6, 2014
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Small molecules plus
transient expression of transcription factors to convert fibroblasts to
pancreatic b cells
expressing transcription factors and treated with small molecules could
provide transplantable pancreatic b cells to help treat
type 1 diabetes. In mouse fibroblast cultures, transient expression of four
pluripotency transcription factors plus delivery of specific small molecule
combinations produced transdifferentiated endoderm-like cells that could be
further converted into pancreatic progenitor-like cells and all three
pancreatic lineages. In a mouse model of hyperglycemia, transplanted
pancreatic progenitor-like cells gave rise to all three pancreatic cell
types, including glucose-responsive, insulin-producing b
cells, which reduced hyperglycemia. Next steps include translating the
approach to human cells and trying to substitute the genetic introduction of
pluripotency factors for noninvasive methods.
Published online March 6, 2014
Patent application filed;
available for licensing
Li, K. et al. Cell Stem
Cell; published online Feb. 6, 2014;
Contact: Sheng Ding, University of California, San
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