Thursday, March 6, 2014
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interspaced short palindromic repeats (CRISPR) genome editing to produce
genetically modified monkeys
Primate studies suggest
CRISPR could be used to develop genetically modified monkeys that model
disease. In single-cell cynomolgus monkey embryos, injection of a pool of
five single guide RNAs (sgRNAs) targeting peroxisome proliferation-activated
activating gene 1 (RAG1) and nuclear
receptor subfamily 0 group B member 1 (NR0B1)
9 (Cas9) mRNA resulted in embryos with
simultaneous disruptions in two target genes. In infant monkeys born after
embryos were transferred to female monkeys, umbilical cord, placenta and ear
puncture tissues from twin monkeys had the same genetic modifications in Pparg
and Rag1. Next steps include developing germline-modified monkeys
using the strategy.
Published online March 6, 2014
unavailable for licensing
Niu, Y. et al. Cell;
published online Jan. 30, 2014;
Contact: Jiahao Sha, Nanjing Medical University, Nanjing, China
Contact: Xingxu Huang, Model Animal Research Center of
Nanjing University, Nanjing, China
Contact: Weizhi Ji, Yunnan Key Laboratory of Primate
Biomedical Research, Kunming, China
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