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Categorization of breast cancers based on expression of vitamin D receptor (VDR), androgen receptor and estrogen receptor

A breast cancer classification system based on expression of three nuclear hormone receptors could help guide prognosis and treatment of the disease. An analysis of normal luminal breast cell differentiation identified four luminal breast cancer categories based on the bimodal expression of VDRs, androgen receptors and estrogen receptors. In samples from patients with breast cancer, the categories correlated with disease outcome, with tumors that did not express the receptors (HR0) having the worst prognosis and tumors expressing all three receptors (HR3) having the best. Next steps include using the system to develop a prognostic test.

SciBX 7(8); doi:10.1038/scibx.2014.242
Published online Feb. 27, 2014

Patent application filed; available for licensing as a diagnostic or prognostic test

Santagata, S. et al. J. Clin. Invest.; published online Jan. 27, 2014;
Contact: Sandro Santagata, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.