Thursday, February 27, 2014
This week in
Publication and contact
Categorization of breast
cancers based on expression of vitamin D
receptor and estrogen
A breast cancer
classification system based on expression of three nuclear hormone receptors
could help guide prognosis and treatment of the disease. An analysis of normal
luminal breast cell differentiation identified four luminal breast cancer
categories based on the bimodal expression of VDRs, androgen receptors and
estrogen receptors. In samples from patients with breast cancer, the
categories correlated with disease outcome, with tumors that did not express
the receptors (HR0) having the worst prognosis and tumors expressing all
three receptors (HR3) having the best. Next steps include using the system to
develop a prognostic test.
Published online Feb. 27, 2014
Patent application filed;
available for licensing as a diagnostic or prognostic test
Santagata, S. et al. J.
Clin. Invest.; published online Jan. 27, 2014;
Contact: Sandro Santagata, Brigham and Women's Hospital and Harvard
Medical School, Boston, Mass.
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