Thursday, February 27, 2014
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Assay & screens
sequencing to evaluate immune response to therapeutic HPV vaccines
sequencing could be used to evaluate immune responses to therapeutic HPV
vaccines. In cervical samples, patients with HPV receiving a therapeutic HPV16
vaccine had about a threefold increase of CD8+ T cell infiltration into lesions compared with
unvaccinated individuals. The vaccinated patients had activated effector
memory T cells and tertiary lymphoid structures, which correlated with
favorable prognosis. High throughput sequencing showed that TCRs in cervical
tissue were not very prevalent in peripheral blood, suggesting monitoring
lesion-specific T cell responses might give a better indication of vaccine
immunogenicity. Next steps could include using the method to monitor
vaccinated patients with HPV in order to determine if therapeutic resection is
Published online Feb. 27, 2014
Patent application pending;
available for licensing
Maldonado, L. et al.
Sci. Transl. Med.; published online Jan. 29, 2014;
Contact: Cornelia L. Trimble, The Johns Hopkins University
School of Medicine, Baltimore, Md.
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