Thursday, February 20, 2014
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A cytosine methylation
signature that predicts overall survival in acute myelogenous leukemia (AML)
Studies of human samples
suggest a cytosine methylation signature can predict overall survival of
patients with AML. A nanoHELP (nano HpaII tiny fragment enrichment by
ligation-mediated PCR) assay identified genome-wide cytosine methylation
patterns in highly purified blood cells from individual patients with AML and
healthy subjects. In the samples from healthy subjects, cytosine methylation
in common myeloid progenitors was lower than that in hematopoietic stem
cells, particularly near promoters of genes involved in hematopoiesis and
leukemogenesis. In the samples from patients with AML, a signature based on
methylation at 561 loci predicted poorer overall survival. Next steps include
testing the signature in prospective clinical trials and developing a simpler
assay to determine the methylation status of loci in the signature.
Published online Feb. 20, 2014
Patent application filed;
available for licensing from the Albert Einstein College of Medicine of Yeshiva
Contact: David Silva, Albert Einstein College of Medicine of
Yeshiva University, Bronx, N.Y.
Bartholdy, B. et al. J.
Clin. Invest.; published online Feb. 3, 2014;
Contact: Ulrich Steidl, Albert Einstein College Of Medicine
of Yeshiva University, Bronx, N.Y.
Contact: Amit Verma, same affiliation as above
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