Thursday, February 20, 2014
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Viral insertion of
inducible aptazymes to improve the safety of oncolytic viral therapy
In vitro studies suggest inducible aptazymes that regulate
viral gene expression could improve the safety of oncolytic viruses.
Aptazymes are self-cleaving ribozymes linked to ligand-binding aptamers that
enable ligand-triggered inhibition of target gene expression. In cancer cells
infected with an adenovirus encoding an aptazyme in the E1A gene,
viral genome replication, infectious particle production and cellular
toxicity were decreased upon ligand exposure compared with what was seen
using unmodified adenovirus or no ligand. The aptazyme also decreased
infectivity of measles virus. Next steps could include assessing the
therapeutic activity of aptazyme-modified oncolytic viruses.
Published online Feb. 20, 2014
Patent and licensing status
Ketzer, P. et al. Proc.
Natl. Acad. Sci. USA; published online
Jan. 21, 2014;
Contact: Dirk M. Nettelbeck, German Cancer Research Center,
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