Thursday, February 20, 2014
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progenitor cells from keratinocytes by depleting the tumor protein p63 (TP63; p63) ΔNp63 isoform or DGCR8 microprocessor complex subunit
In vitro studies suggest depleting ΔNp63 or DGCR8
in keratinocytes could induce their conversion into multipotent stem cells.
In mouse or human epidermal cells, shRNA
against or knockout of ΔNp63 and DGCR8 increased
expression of pluripotency markers compared with control shRNA or no alteration and allowed
differentiation into multiple cell types. Restoring DGCR8 expression
repressed expression of pluripotency markers. In mice, injection of green
fluorescent protein-labeled ΔNp63 mutant epidermal cells into
blastocyst-stage embryos led to their incorporation into differentiated
tissues at levels similar to those for induced pluripotent stem (iPS) cells.
Next steps include using the strategy to differentiate cells for cell
Published online Feb. 20, 2014
Patent application filed;
available for licensing
Chakravarti, D. et al.
Proc. Natl. Acad. Sci. USA; published online Jan. 21, 2014;
Contact: Elsa R. Flores, The University of Texas MD Anderson
Cancer Center, Houston, Texas
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