Thursday, February 20, 2014
Publication and contact
Improved brain delivery of
anti-transferrin receptor (TFRC;
antibodies by reducing TFRC affinity
Mouse studies suggest
lowering anti-TFRC antibody affinity could increase brain uptake of blood
brain barrier (BBB)-penetrant, bispecific antibodies. In mice, a bispecific,
anti-TFRC and anti-b-amyloid cleaving enzyme 1 (BACE1) antibody with low
affinity for TFRC led to increased surface-expressed Tfrc levels on BBB
endothelial cells and increased BBB trafficking and brain uptake compared
with a related antibody with high affinity for TFRC. This relative increase
in surface-expressed Tfrc was seen because the low-affinity antibody induced less
lysosome-mediated degradation of Tfrc than the high-affinity antibody.
Ongoing work includes validating the approach in nonhuman primates.
Published online Feb. 20, 2014
Patent and licensing status
Bien-Ly, N. et al. J.
Exp. Med.; published online Jan. 27, 2014;
Contact: Ryan J. Watts, Genentech Inc., South San Francisco,
Contact: Inhee Chung, same affiliation as above
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]