Thursday, February 20, 2014
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Assays & screens
compounds using microfluidic-based tracking of cell migration
A microfluidic device that
monitors cell migration could be used to screen antimetastatic compounds. On
the chip-based device, chemoattractant loaded at one end of 10 separate
microchannels induced the migration of cells loaded at the other end of each
microchannel, which could be tracked with scanning electron microscopy. The
device simultaneously screened nine research-grade, clinical or marketed
small molecule inhibitors of metastasis-associated targets for their ability
to increase or decrease the migration of paclitaxel-resistant
metastatic human breast cancer cells compared with no treatment. Future
studies could include using the device to screen new inhibitors of cell
migration and metastasis.
Published online Feb. 20, 2014
Patent and licensing status
Zhang, Y. et al. Angew.
Chem. Int. Ed.; published online Jan. 29, 2014;
Contact: Lidong Qin, Houston Methodist Research Institute, Houston,
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