Thursday, February 20, 2014
Publication and contact
Assays & screens
compounds using microfluidic-based tracking of cell migration
A microfluidic device that
monitors cell migration could be used to screen antimetastatic compounds. On
the chip-based device, chemoattractant loaded at one end of 10 separate
microchannels induced the migration of cells loaded at the other end of each
microchannel, which could be tracked with scanning electron microscopy. The
device simultaneously screened nine research-grade, clinical or marketed
small molecule inhibitors of metastasis-associated targets for their ability
to increase or decrease the migration of paclitaxel-resistant
metastatic human breast cancer cells compared with no treatment. Future
studies could include using the device to screen new inhibitors of cell
migration and metastasis.
Published online Feb. 20, 2014
Patent and licensing status
Zhang, Y. et al. Angew.
Chem. Int. Ed.; published online Jan. 29, 2014;
Contact: Lidong Qin, Houston Methodist Research Institute, Houston,
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]