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Disease models

Modeling the effect of hyperactive mast cells in inflammatory disease

Mice with hyperactive mast cells could help model inflammatory diseases. In cell culture, tumor necrosis factor-a-induced protein 3 (TNFAIP3; A20) depletion enhanced lipopolysaccharide (LPS)- and IL-33 (NF-HEV)-induced mast cell activation. In mice, A20 depletion in mast cells induced a sensitized state without eliciting spontaneous inflammation. In mouse models of asthma, allergic asthma and rheumatoid arthritis (RA), A20 depletion in mast cells exacerbated inflammatory responses. In mouse models of multiple sclerosis (MS), A20 depletion in mast cells had no effect. Next steps include finding methods to stabilize A20 protein to reduce inflammation and studying the role of hyperinflammatory mast cells in cancer.

SciBX 7(6); doi:10.1038/scibx.2014.183
Published online Feb. 13, 2014

Unpatented; licensing status not applicable

Heger, K. et al. PLoS Biol.;
published online Jan. 14, 2014;
Contact: Marc Schmidt-Supprian, Max Planck Institute of Biochemistry, Martinsried, Germany