Thursday, February 13, 2014
This week in
Publication and contact
Modeling the effect of
hyperactive mast cells in inflammatory disease
with hyperactive mast cells could help model inflammatory diseases. In cell
protein 3 (TNFAIP3;
depletion enhanced lipopolysaccharide
mast cell activation. In mice, A20 depletion in mast cells induced a
sensitized state without eliciting spontaneous inflammation. In mouse models
of asthma, allergic asthma and rheumatoid arthritis (RA), A20
depletion in mast cells exacerbated inflammatory responses. In mouse models
of multiple sclerosis (MS), A20 depletion in mast cells had no effect.
Next steps include finding methods to stabilize A20 protein to reduce
inflammation and studying the role of hyperinflammatory mast cells in cancer.
Published online Feb. 13, 2014
status not applicable
Heger, K. et al. PLoS
published online Jan. 14, 2014;
Contact: Marc Schmidt-Supprian, Max Planck Institute of
Biochemistry, Martinsried, Germany
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]