Thursday, February 13, 2014
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Modeling the effect of
hyperactive mast cells in inflammatory disease
with hyperactive mast cells could help model inflammatory diseases. In cell
protein 3 (TNFAIP3;
depletion enhanced lipopolysaccharide
mast cell activation. In mice, A20 depletion in mast cells induced a
sensitized state without eliciting spontaneous inflammation. In mouse models
of asthma, allergic asthma and rheumatoid arthritis (RA), A20
depletion in mast cells exacerbated inflammatory responses. In mouse models
of multiple sclerosis (MS), A20 depletion in mast cells had no effect.
Next steps include finding methods to stabilize A20 protein to reduce
inflammation and studying the role of hyperinflammatory mast cells in cancer.
Published online Feb. 13, 2014
status not applicable
Heger, K. et al. PLoS
published online Jan. 14, 2014;
Contact: Marc Schmidt-Supprian, Max Planck Institute of
Biochemistry, Martinsried, Germany
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