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In vivo imaging of CD8+ T cells using radiolabeled antibody fragments

Mouse studies suggest radiolabeled antibody fragments targeting CD8 could help monitor leukemia disease progression. Two antibody fragments based on mouse Cd8-depleting antibodies were designed that maintained antigen binding but did not deplete T cells. In normal mice, immuno-PET imaging detected accumulation of radiolabeled antibody fragments in the spleen and lymph nodes; the accumulation was decreased in Cd8-depleted, Cd8-blocked or immunodeficient mice. Next steps include designing an anti-human CD8 antibody fragment for clinical imaging.

SciBX 7(5); doi:10.1038/scibx.2014.158
Published online Feb. 6, 2014

Patent application filed; licensing negotiations ongoing; unavailable for licensing

Tavaré, R. et al. Proc. Natl. Acad. Sci. USA; published online Jan. 3, 2014;
Contact: Anna M. Wu, University of California, Los Angeles, Calif.