Thursday, February 6, 2014
Publication and contact
delivery devices for sustained, near infrared (NIR) light-inducible release
Rat studies suggest an NIR
light-activated device could enable controlled, repeated, sustained drug
delivery. The device incorporates a drug reservoir encapsulated by an
ethylcellulose matrix containing heat-sensitive gold nanoparticles. In
saline, continuous-wave NIR light or heat stimulated the nanoparticles to
create a porous membrane and release drug in a sustained manner. In diabetic
rats, subcutaneous implantation of the device loaded with insulin followed by
activation with periodic laser pulses decreased blood glucose levels
coincident with NIR light trigger compared with what was seen in
saline-loaded controls or with untriggered devices. Next steps include
developing formulations that can be triggered by lower laser powers to
Published online Feb. 6, 2014
Patent application filed;
available for licensing
Timko, B.P. et al. Proc.
Natl. Acad. Sci. USA; published online Jan. 13, 2014;
Contact: Daniel S. Kohane, Boston Children's Hospital, Boston,
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]