Thursday, February 6, 2014
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delivery devices for sustained, near infrared (NIR) light-inducible release
Rat studies suggest an NIR
light-activated device could enable controlled, repeated, sustained drug
delivery. The device incorporates a drug reservoir encapsulated by an
ethylcellulose matrix containing heat-sensitive gold nanoparticles. In
saline, continuous-wave NIR light or heat stimulated the nanoparticles to
create a porous membrane and release drug in a sustained manner. In diabetic
rats, subcutaneous implantation of the device loaded with insulin followed by
activation with periodic laser pulses decreased blood glucose levels
coincident with NIR light trigger compared with what was seen in
saline-loaded controls or with untriggered devices. Next steps include
developing formulations that can be triggered by lower laser powers to
Published online Feb. 6, 2014
Patent application filed;
available for licensing
Timko, B.P. et al. Proc.
Natl. Acad. Sci. USA; published online Jan. 13, 2014;
Contact: Daniel S. Kohane, Boston Children's Hospital, Boston,
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