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Fc g-receptor IIc (CD32C; FCGR2C) variants predict responses to vaccines

Human studies suggest expression of CD32C could help predict patient responses to vaccines. CD32C normally contains a termination codon, but 7%-15% of individuals carry a mutation that changes it into a full-length open reading frame. Individuals with this variant expressed CD32C on B cells and were more likely to respond to an anthrax vaccine than patients that did not express the variant. Individuals with the full-length CD32C variant also were more likely to develop the autoimmune disease systemic lupus erythematosus (SLE) than those without the variant. Next steps could include validating the association of the variant with immune responses in additional individuals.

SciBX 7(4); doi:10.1038/scibx.2014.131
Published online Jan. 30, 2014

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Li, X. et al. Sci. Transl. Med.; published online Dec. 18, 2013;
Contact: Robert P. Kimberly, The University of Alabama at
Birmingham, Ala.
Contact: Jeffrey C. Edberg, same affiliation as above