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Magnetic resonance spectroscopy (MRS) of hyperpolarized (2H,13C)-labeled glucose to detect tumor response to drug treatment

Mouse studies suggest MRS using a hyperpolarized (2H,13C)-labeled glucose probe could help detect tumor responses to drug treatment. In mouse models of T cell lymphoma and lung cancer, MRS using the probe detected the glycolysis product (2H,13C)-labeled lactate in tumors within 15 seconds but not in normal tissues. In chemotherapy-treated mouse models of T cell lymphoma, MRS using the probe showed that the intratumoral ratio of lactate to glucose signals decreased by 62% 24 hours after treatment compared with no treatment. Planned work includes comparing the sensitivity of the method and 18F-labeled fluorodeoxyglucose PET imaging in tumor models.

SciBX 7(3); doi:10.1038/scibx.2014.103
Published online Jan. 23, 2014

Unpatented; unlicensed

Rodrigues, T.B. et al. Nat. Med.; published online Dec. 8, 2013;
Contact: Kevin M. Brindle, University of Cambridge, Cambridge, U.K.