Thursday, January 23, 2014
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nephron progenitor cells and self-organizing 3D structures
pluripotent cells into nephron progenitors could help model and treat renal
diseases. A three-step, ex vivo differentiation protocol involving
culture in growth factors including activin A
morphogenetic protein 4 (BMP4)
or a wingless-type
MMTV integration site (WNT)
agonist followed by fibroblast
growth factor 9
converted human embryonic stem cells (hESCs) into nephron progenitor cells.
Differentiated hESCs self-organized into nephron-forming structures ex vivo.
The process was similar to what occurs with dissociated then reaggregated
mouse embryonic kidneys. Next steps could include developing the system for
nephrotoxicity screens, ex vivo disease modeling and the generation of
Published online Jan. 23, 2014
Patent and licensing status
Takasato, M. et al. Nat.
Cell Biol.; published online Dec. 15, 2013;
Contact: M.H. Little, The University of Queensland,
Brisbane, Queensland, Australia
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