Thursday, January 23, 2014
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Assays & screens
HCRT)-based immunoassays to diagnose narcolepsy
Immunoassays to determine T
cell reactivity to two HCRT epitopes could be used to diagnose narcolepsy.
Narcolepsy has been associated with human
leukocyte antigen (HLA)
DQ0602, but no molecular diagnostics for the condition exist. In coculture
with an HLA DQ0602-specific T-B fusion cell line treated with HCRT56-68
or HCRT87-99, T cells obtained from narcoleptic individuals showed
strong HCRT peptide-specific CD4+ T cell reactivity. Statistical analysis of the
assay identified 19 of 23 patients with narcolepsy and 24 of 24 unaffected
individuals. Next steps could include using the assay on larger patient
cohorts and evaluating association of T cell reactivity with HCRT levels in
patient spinal fluid (see Diagnosing narcolepsy, page 9).
Published online Jan. 23, 2014
Patent application filed by
University for HCRT epitopes for narcolepsy diagnosis;
licensing status unavailable
De la Herrán-Arita, A.K. et
Sci. Transl. Med.; published online
Dec. 18, 2013;
Contact: Emmanuel Mignot, Stanford University School of
Medicine, Stanford, Calif.
Contact: Elizabeth D. Mellins,
same affiliation as above
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