Thursday, January 16, 2014
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Synthetic, homogenous erythropoietin (EPO)
Solid-phase synthesis of
homogenous, glycosylated EPO could lead to synthetic approaches for
manufacture of biologics. Four oligosaccharides were synthesized and attached
to peptide fragments obtained by solid-phase peptide synthesis. The
glycosylated peptides were assembled by chemical ligation to yield homogenous
EPO with one O-linked and three N-linked glycans. After assembly, EPO was
folded. In a cultured, bone marrow-derived cell line and in mice, synthetic
EPO exhibited activity comparable to Procrit. Next steps include
synthesis of mutant proteins with oncogenic properties.
& Johnson markets Procrit recombinant EPO to treat
Published online Jan. 16, 2014
Patent pending; available
Wang, P. et al. Science;
published online Dec. 13, 2013;
Contact: Samuel J. Danishefsky, Sloan Kettering Institute, Memorial
Sloan Kettering Cancer Center, New York, N.Y.
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