Thursday, January 9, 2014
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Testis expressed 101 (TEX101) and extracellular matrix protein 1
(ECM1) as biomarkers to
identify subtypes of infertile azoospermia patients
TEX101 and ECM1 could be
used as infertility biomarkers to help identify patients with azoospermia.
Azoospermia patients do not produce measurable levels of sperm in semen, and
current methods to diagnose the condition require a testicular biopsy. In
seminal plasma samples from patients with two distinct types of azoospermia,
ECM1 levels distinguished between the 2 conditions with 100% sensitivity and
73% specificity and identified azoospermia patients from fertile controls
with 100% specificity. In the samples, high levels of TEX101 could further
distinguish subtypes of the disease, which could help guide assisted
reproduction technique choices. Next steps include developing clinical-grade
assays and validating the assays for clinical applications.
Published online Jan. 9, 2014
Patent filed covering
biomarkers; licensed in the U.S. to an undisclosed company; available for
licensing in Europe
Drabovich, A.P. et al.
Sci. Transl. Med.; published online Nov. 20, 2013;
Contact: Eleftherios P. Diamandis, Mount Sinai Hospital,
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