Thursday, January 9, 2014
Publication and contact
Testis expressed 101 (TEX101) and extracellular matrix protein 1
(ECM1) as biomarkers to
identify subtypes of infertile azoospermia patients
TEX101 and ECM1 could be
used as infertility biomarkers to help identify patients with azoospermia.
Azoospermia patients do not produce measurable levels of sperm in semen, and
current methods to diagnose the condition require a testicular biopsy. In
seminal plasma samples from patients with two distinct types of azoospermia,
ECM1 levels distinguished between the 2 conditions with 100% sensitivity and
73% specificity and identified azoospermia patients from fertile controls
with 100% specificity. In the samples, high levels of TEX101 could further
distinguish subtypes of the disease, which could help guide assisted
reproduction technique choices. Next steps include developing clinical-grade
assays and validating the assays for clinical applications.
Published online Jan. 9, 2014
Patent filed covering
biomarkers; licensed in the U.S. to an undisclosed company; available for
licensing in Europe
Drabovich, A.P. et al.
Sci. Transl. Med.; published online Nov. 20, 2013;
Contact: Eleftherios P. Diamandis, Mount Sinai Hospital,
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]