Thursday, January 9, 2014
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fluorescent nanoprobe-based nanoparticles for tumor imaging
nanoparticles could be used to specifically label tumors in vivo. UPS,
fluorescent nanoprobes were designed that self-assembled to form micelle-like
nanoparticles lacking fluorescence because of fluorophore quenching. In mice
with glycolytic lung cancer tumors, i.v. injection of the nanoparticles led
to uptake and dissociation of the nanoparticle in the tumor and activated a
strong fluorescent signal that could be used for tumor imaging. In mice with
angiogenic lung tumors, i.v. injection of RGD peptide-modified nanoparticles
led to uptake and dissociation by integrin aVb3 (CD51/CD61)-mediated
endocytosis, activating a strong fluorescent signal that could be used for
tumor imaging. Similar imaging results for the nanoparticle method were
obtained in 10 different mouse models of cancer with diverse phenotypes and
organ sites. Next steps include obtaining safety data and translating the
technology for fluorescence-guided surgical resection of solid tumors (see
up, page 1).
SciBX 7(1); doi:10.1038/scibx.2014.37
Published online Jan. 9, 2014
Patent application filed;
available for licensing
Wang, Y. et al. Nat.
Mater.; published online Dec. 8, 2013;
Contact: Jinming Gao, The University of Texas Southwestern
Medical Center, Dallas, Texas
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