Thursday, January 9, 2014
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Differentiation of human
induced pluripotent stem (iPS) cells into renal progenitor-like cells with
In vitro studies identified culture conditions that
differentiated iPS cells into renal progenitor-like cells for kidney disease
modeling or cell-based therapy. In iPS cell cultures, addition of bone
morphogenetic protein 4 (BMP4)
and fibroblast growth factor 2
(FGF2) followed by retinoic
acid, activin A and BMP2 induced
differentiation into cells expressing renal lineage markers. In coculture
with mouse embryonic kidney cells, human iPS cell-derived renal cells from
healthy individuals and patients with polycystic kidney disease (PKD) formed
chimeric 3D ureteric bud structures. Next steps include testing the
therapeutic potential of the method in animal models of kidney injury.
Published online Jan. 9, 2014
application filed; available for licensing
Xia, Y. et al. Nat. Cell
Biol.; published online Nov. 17, 2013;
Contact: Juan Carlos Izpisua Belmonte, Salk Institute for
La Jolla, Calif.
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