Thursday, January 9, 2014
Publication and contact
Differentiation of human
induced pluripotent stem (iPS) cells into renal progenitor-like cells with
In vitro studies identified culture conditions that
differentiated iPS cells into renal progenitor-like cells for kidney disease
modeling or cell-based therapy. In iPS cell cultures, addition of bone
morphogenetic protein 4 (BMP4)
and fibroblast growth factor 2
(FGF2) followed by retinoic
acid, activin A and BMP2 induced
differentiation into cells expressing renal lineage markers. In coculture
with mouse embryonic kidney cells, human iPS cell-derived renal cells from
healthy individuals and patients with polycystic kidney disease (PKD) formed
chimeric 3D ureteric bud structures. Next steps include testing the
therapeutic potential of the method in animal models of kidney injury.
Published online Jan. 9, 2014
application filed; available for licensing
Xia, Y. et al. Nat. Cell
Biol.; published online Nov. 17, 2013;
Contact: Juan Carlos Izpisua Belmonte, Salk Institute for
La Jolla, Calif.
firstname.lastname@example.org or email@example.com
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]