Thursday, January 9, 2014
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Local drug eluter (LODER)
for the prolonged delivery of siRNA
Delivery of siRNA targeting
mutant K-Ras (KRAS) using LODER could
help treat pancreatic cancers. LODER is a miniature biodegradable polymeric
matrix that contains drug or siRNA. In human pancreatic cancer cells
expressing mutant KRAS G12D, LODER delivery of G12D-targeting siRNA inhibited
cell growth. In mice with mutant KRAS-expressing human pancreatic cancer
xenografts, intratumoral implantation of LODER containing siRNA targeting
mutant KRAS decreased tumor volume compared with implantation of empty LODER
or with no treatment. In mice with orthotopic pancreatic tumors, intratumoral
implantation of LODER carrying siRNA targeting mutant KRAS decreased tumor
growth compared with implantation of empty LODER and extended overall
survival. Next steps include a Phase II/III clinical trial in G12D-mutant
pancreatic cancer by Silenseed Ltd. (See Silencing KRAS, page 8.)
Published online Jan. 9, 2014
Patent applications filed
by Silenseed; available for licensing for non-oncology indications and on a
per-case basis for oncology indications
Khvalevsky, E.Z. et al.
Proc. Natl. Acad. Sci. USA; published online
Dec. 2, 2013;
Contact: Eithan Galun, Hadassah Medical Center, Jerusalem, Israel
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