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Assays & screens

Serum factor protein microarrays to identify autoreactive antibodies in patients with autoimmune disease

Serum factor microarrays that identify autoreactive antibodies could help identify therapeutic targets in autoimmune diseases. Microarrays were designed and coated with human cytokines, chemokines and autoimmune tissue antigens that could bind to specific autoreactive antibodies. In sera from patients with systemic lupus erythematosus (SLE), autoreactive antibodies for known and new targets, including BLyS (BAFF), were detected by the assay. Next steps include using the microarray technology to screen for new targets for autoimmune diseases and to stratify patients for clinical trials.
GlaxoSmithKline plc markets the anti-BLyS antibody Benlysta belimumab to treat lupus. At least five other companies have BLyS inhibitors or antibodies in Phase III or earlier testing.

SciBX 7(1); doi:10.1038/scibx.2014.31
Published online Jan. 9, 2014

Unpatented; unavailable for licensing

Price, J.V. et al. J. Clin. Invest.; published online Nov. 25, 2013;
Contact: Paul J. Utz, Stanford University, Stanford, Calif.
Contact: Jordan V. Price, same affiliation as above