Thursday, January 9, 2014
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Assays & screens
Serum factor protein
microarrays to identify autoreactive antibodies in patients with autoimmune
Serum factor microarrays
that identify autoreactive antibodies could help identify therapeutic targets
in autoimmune diseases. Microarrays were designed and coated with human
cytokines, chemokines and autoimmune tissue antigens that could bind to
specific autoreactive antibodies. In sera from patients with systemic lupus
erythematosus (SLE), autoreactive antibodies for known and new targets,
including BLyS (BAFF), were detected by the
assay. Next steps include using the microarray technology to screen for new
targets for autoimmune diseases and to stratify patients for clinical trials.
GlaxoSmithKline plc markets
the anti-BLyS antibody Benlysta belimumab to treat
lupus. At least five other companies have BLyS inhibitors or antibodies in
Phase III or earlier testing.
Published online Jan. 9, 2014
Unpatented; unavailable for
Price, J.V. et al. J.
Clin. Invest.; published online Nov. 25, 2013;
Contact: Paul J. Utz, Stanford University, Stanford, Calif.
Contact: Jordan V. Price, same affiliation as above
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