Thursday, December 19, 2013
Publication and contact
Spherical nucleic acid
(SNA) nanoparticle conjugates to knock down oncogene expression
Systemic delivery of SNAs
conjugated to siRNAs could be used to treat glioma. SNAs consist of gold
nanoparticles covalently modified with densely packed, oriented siRNA duplexes.
In cultured human glioma cell lines and patient- and mouse-derived
neurospheres, SNAs conjugated to siRNAs targeting BCL2-like
decreased expression of BCL2L12 compared with SNAs conjugated to scrambled
siRNAs. In mouse models of human glioma, i.v. injection of the SNAs led to
their accumulation in tumor but not normal tissue, and SNAs conjugated to
siRNAs targeting BCL2L12 decreased expression of BCL2L12 protein and
RNA, decreased tumor burden and increased survival compared with control
SNAs. Next steps could include elucidating the mechanism of SNA uptake into
glioma cells and tumors or using SNA-based systemic delivery of siRNAs to
Published online Dec. 19, 2013
Patent and licensing status
Jensen, S.A. et al. Sci.
Transl. Med.; published online Oct. 30, 2013;
Contact: Alexander H. Stegh, Northwestern University,
Contact: Chad A. Mirkin, same affiliation as above
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]