Thursday, December 19, 2013
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Spherical nucleic acid
(SNA) nanoparticle conjugates to knock down oncogene expression
Systemic delivery of SNAs
conjugated to siRNAs could be used to treat glioma. SNAs consist of gold
nanoparticles covalently modified with densely packed, oriented siRNA duplexes.
In cultured human glioma cell lines and patient- and mouse-derived
neurospheres, SNAs conjugated to siRNAs targeting BCL2-like
decreased expression of BCL2L12 compared with SNAs conjugated to scrambled
siRNAs. In mouse models of human glioma, i.v. injection of the SNAs led to
their accumulation in tumor but not normal tissue, and SNAs conjugated to
siRNAs targeting BCL2L12 decreased expression of BCL2L12 protein and
RNA, decreased tumor burden and increased survival compared with control
SNAs. Next steps could include elucidating the mechanism of SNA uptake into
glioma cells and tumors or using SNA-based systemic delivery of siRNAs to
Published online Dec. 19, 2013
Patent and licensing status
Jensen, S.A. et al. Sci.
Transl. Med.; published online Oct. 30, 2013;
Contact: Alexander H. Stegh, Northwestern University,
Contact: Chad A. Mirkin, same affiliation as above
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