Thursday, December 19, 2013
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Olfactory ensheathing cells
(OECs) to increase myelination
Cell culture studies
suggest OECs might make better transplant cells for spinal injury repair than
Schwann cells. In cocultures of an astrocyte monolayer and a mixed embryonic
spinal cord cell suspension, OECs increased levels of myelination compared
with Schwann cells, which decreased levels of myelination. In the cocultures,
media conditioned by Schwann cells also decreased levels of myelination
compared with no treatment, which could be reversed with an antibody
tissue growth factor (CTGF).
Next steps include identifying mechanisms that could confer OEC properties on
Published online Dec. 19, 2013
status not applicable
Lamond, R. & Barnett,
S.C. J. Neurosci.; published online Nov. 20, 2013;
Contact: Susan C. Barnett, University of Glasgow, Glasgow,
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