Thursday, December 19, 2013
Publication and contact
Lin-28 homolog A
metabolic reprogramming for tissue repair
Mouse studies suggest
elevating LIN28A activity could help promote tissue regeneration after injury
or in advanced age. In tissue injury assays in mice, Lin28a overexpression
promoted regrowth of shaved hair and regeneration of amputated digits and
complex tissues. The regenerative effects of Lin28a depended on repression of
and enhanced translation of Lin28a-bound mRNAs encoding key enzymes for
glycolysis and oxidative phosphorylation. In shaved, Lin28a-overexpressing
mice, pharmacological inhibition of glycolysis and oxidative phosphorylation
suppressed hair regrowth. Next steps could include identifying stimulators of
activity in regenerating tissues.
Published online Dec. 19, 2013
Patent and licensing status
Shyh-Chang, N. et al.
published online Nov. 7, 2013;
Contact: George Q. Daley, Boston Children's Hospital and
Dana-Farber Cancer Institute, Boston, Mass.
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]