Thursday, December 19, 2013
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Lin-28 homolog A
metabolic reprogramming for tissue repair
Mouse studies suggest
elevating LIN28A activity could help promote tissue regeneration after injury
or in advanced age. In tissue injury assays in mice, Lin28a overexpression
promoted regrowth of shaved hair and regeneration of amputated digits and
complex tissues. The regenerative effects of Lin28a depended on repression of
and enhanced translation of Lin28a-bound mRNAs encoding key enzymes for
glycolysis and oxidative phosphorylation. In shaved, Lin28a-overexpressing
mice, pharmacological inhibition of glycolysis and oxidative phosphorylation
suppressed hair regrowth. Next steps could include identifying stimulators of
activity in regenerating tissues.
Published online Dec. 19, 2013
Patent and licensing status
Shyh-Chang, N. et al.
published online Nov. 7, 2013;
Contact: George Q. Daley, Boston Children's Hospital and
Dana-Farber Cancer Institute, Boston, Mass.
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