Thursday, December 19, 2013
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Fc fragment of IgG receptor transporter-a (FCGRT;
nanoparticles for oral nanoparticle delivery
In vitro and mouse studies suggest FCRN-targeted
nanoparticles could be used for oral drug delivery. Polylactic acid (PLA)-polyethylene
glycol (PEG) nanoparticles with an IgG Fc fragment conjugated to the PEG
shell had increased transport across a human epithelial colorectal
adenocarcinoma monolayer and across the intestinal epithelium in mice
compared with untargeted controls. In fasted mice, oral Fcrn-targeted
nanoparticles encapsulating insulin caused a hypoglycemic response
that lasted longer than injection of free insulin, whereas oral delivery of
untargeted nanoparticles had no effect. Next steps include testing whether
the nanoparticle platform can be used for delivery across other biological
barriers (see Oral nanoparticles, page 1).
Published online Dec. 19, 2013
Patent application filed;
available for licensing
Pridgen, E.M. et al.
Sci. Transl. Med.; published online Nov. 27, 2013;
Contact: Omid C. Farokhzad, Brigham and Women's Hospital,
Contact: Frank Alexis, Harvard Medical School, Boston, Mass.
Contact: Rohit Karnik, Massachusetts Institute of
Technology, Cambridge, Mass.
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