Thursday, December 19, 2013
Publication and contact
Fc fragment of IgG receptor transporter-a (FCGRT;
nanoparticles for oral nanoparticle delivery
In vitro and mouse studies suggest FCRN-targeted
nanoparticles could be used for oral drug delivery. Polylactic acid (PLA)-polyethylene
glycol (PEG) nanoparticles with an IgG Fc fragment conjugated to the PEG
shell had increased transport across a human epithelial colorectal
adenocarcinoma monolayer and across the intestinal epithelium in mice
compared with untargeted controls. In fasted mice, oral Fcrn-targeted
nanoparticles encapsulating insulin caused a hypoglycemic response
that lasted longer than injection of free insulin, whereas oral delivery of
untargeted nanoparticles had no effect. Next steps include testing whether
the nanoparticle platform can be used for delivery across other biological
barriers (see Oral nanoparticles, page 1).
Published online Dec. 19, 2013
Patent application filed;
available for licensing
Pridgen, E.M. et al.
Sci. Transl. Med.; published online Nov. 27, 2013;
Contact: Omid C. Farokhzad, Brigham and Women's Hospital,
Contact: Frank Alexis, Harvard Medical School, Boston, Mass.
Contact: Rohit Karnik, Massachusetts Institute of
Technology, Cambridge, Mass.
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]