Thursday, December 19, 2013
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mouse model of autism
Mice with a heterozygous,
autism-linked Pten deletion could be used to screen therapeutics for
autism spectrum disorder. Brain slices from heterozygous Pten
knockouts had higher levels of potassium
channel KCa2.2 (Kcnn2)
and had lower excitatory response after electrical and pharmacological
stimulation than brain slices from wild-type controls. Next steps could
include testing the effect of KCNN2 antagonists on neuronal excitability.
Acesion Pharma ApS has
inhibitors of KCNN2 and other small conductance calcium-activated potassium
channels in discovery stage development to treat atrial fibrillation (AF).
Published online Dec. 19, 2013
Patent and licensing status
Garcia-Junco-Clemente, P. et
Proc. Natl. Acad. Sci. USA;
published online Oct. 21, 2013;
Contact: Peyman Golshani, University of California, Los Angeles
David Geffen School of Medicine, Los Angeles, Calif.
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