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Disease models

Pten (Mmac1; Tep1)-mutant mouse model of autism

Mice with a heterozygous, autism-linked Pten deletion could be used to screen therapeutics for autism spectrum disorder. Brain slices from heterozygous Pten knockouts had higher levels of potassium channel KCa2.2 (Kcnn2) and had lower excitatory response after electrical and pharmacological stimulation than brain slices from wild-type controls. Next steps could include testing the effect of KCNN2 antagonists on neuronal excitability.
Acesion Pharma ApS has inhibitors of KCNN2 and other small conductance calcium-activated potassium channels in discovery stage development to treat atrial fibrillation (AF).

SciBX 6(48); doi:10.1038/scibx.2013.1405
Published online Dec. 19, 2013

Patent and licensing status undisclosed

Garcia-Junco-Clemente, P. et al.
Proc. Natl. Acad. Sci. USA
published online Oct. 21, 2013;
Contact: Peyman Golshani, University of California, Los Angeles David Geffen School of Medicine, Los Angeles, Calif.