Thursday, December 19, 2013
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Assays & screens
Monitoring cell-free DNA in
plasma to predict organ transplant rejection
Cell-free DNA in plasma
could be used to quantify viral load and predict risk of transplant
rejection. In plasma obtained from patients that received heart or lung
transplants, cell-free DNA was sequenced to identify changes in virus
populations and quantify viral load. The data were analyzed to find
correlations between antiviral and immunosuppressant regimes, viral load and
risk of organ rejection. Decreased burden of anellovirus post-transplantation
correlated with increased organ rejection, which was thought to reflect an
increased level of patient immunocompetence. Next steps include using the
method in larger patient cohorts and patients undergoing organ transplants
other than heart and lung.
Laboratories Inc. markets ImmuKnow,
an immune cell function assay that detects cell-mediated immune response in
patients undergoing immunosuppressive therapy for organ transplant.
Published online Dec. 19, 2013
Patent and licensing status
De Vlaminck, I. et al.
published online Nov. 21, 2013;
Contact: Stephen R. Quake, Stanford University, Stanford,
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