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Drug delivery

Staggered lamellae nanostructures for drug delivery

Staggered lamellae polyprodrug nanostructures could be useful for drug delivery. In water and dioxane mixtures, staggered lamellae structures with spiked periphery and 300 nm diameters self-assembled from amphiphilic block copolymers made up of hydrophilic poly(ethylene glycol) (PEG) and polymerized, reduction-responsive camptothecin prodrug monomers. In HeLa cells, the lamellae nanostructures were internalized faster than disk-, sphere- or flower-like polyprodrug nanostructures and released drug under reducing conditions, which mimic tumor intracellular microenvironments. In healthy rats i.v. injected with the particles, the lamellae polyprodrug nanostructures had longer half-lives than the other nanostructures. Next steps include testing the antitumor effects of the four types of self-assembled nanostructures in mouse xenograft models.

SciBX 6(47); doi:10.1038/scibx.2013.1366
Published online Dec. 12, 2013

Patent application filed; available for licensing

Hu, X. et al. J. Am. Chem. Soc.; published online Oct. 25, 2013;
Contact: Shiyong Liu University of Science and Technology of China, Hefei, China

Contact: Jinming Hu, same affiliation as above