Thursday, December 5, 2013
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co-delivery of small interfering RNA and cisplatin
nanoparticles that co-deliver siRNA and a cisplatin prodrug could improve
cancer chemotherapy response. The nanoparticles, consisting of a biodegradable
diblock copolymer and a self-synthesized cationic lipid, are loaded with a
cisplatin prodrug and siRNAs targeting REV1
and REV3-like catalytic subunit of DNA polymerase-z (REV3L). In mouse xenograft
models of human prostate cancer, siRNA- and prodrug-loaded nanoparticles led
to decreased tumor growth and increased survival compared with nanoparticles
loaded with the prodrug or siRNAs alone. Next steps could include evaluating
delivery of different siRNA and drug payload combinations with the
Published online Dec. 5, 2013
Patent and licensing status
Xu, X. et al. Proc.
Natl. Acad. Sci. USA; published online Oct. 28, 2013;
Contact: Omid C. Farokhzad, Harvard Medical School, Boston,
Contact: Graham C. Walker, Massachusetts Institute of
Technology, Cambridge, Mass.
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