Thursday, December 5, 2013
Publication and contact
co-delivery of small interfering RNA and cisplatin
nanoparticles that co-deliver siRNA and a cisplatin prodrug could improve
cancer chemotherapy response. The nanoparticles, consisting of a biodegradable
diblock copolymer and a self-synthesized cationic lipid, are loaded with a
cisplatin prodrug and siRNAs targeting REV1
and REV3-like catalytic subunit of DNA polymerase-z (REV3L). In mouse xenograft
models of human prostate cancer, siRNA- and prodrug-loaded nanoparticles led
to decreased tumor growth and increased survival compared with nanoparticles
loaded with the prodrug or siRNAs alone. Next steps could include evaluating
delivery of different siRNA and drug payload combinations with the
Published online Dec. 5, 2013
Patent and licensing status
Xu, X. et al. Proc.
Natl. Acad. Sci. USA; published online Oct. 28, 2013;
Contact: Omid C. Farokhzad, Harvard Medical School, Boston,
Contact: Graham C. Walker, Massachusetts Institute of
Technology, Cambridge, Mass.
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]