Thursday, December 5, 2013
Publication and contact
Mouse model of intrahepatic
Orthotopic allograft mouse
models of ICC could be used to validate drivers of the disease. In mice,
intrahepatic implantation of mouse liver progenitor cells
expressing mutant forms of p53 and K-Ras (KRAS) caused development of
tumors with histological features of ICC, including stromal cell
infiltration. In the model, induced expression of a fusion gene
containing Golgi-associated PDZ and coiled-coil motif
containing (GOPC; FIG) linked to c-ros proto-oncogene 1 receptor tyrosine kinase (ROS1), which has been
found in a subset of patients with ICC, accelerated tumor growth. In the
mouse model with established tumors that expressed the fusion gene, turning
off its expression prevented further tumor growth. Next steps could
include using the model to validate additional ICC targets.
Published online Dec. 5, 2013
Patent and licensing status
Saborowski, A. et
al. Proc. Natl. Acad. Sci. USA; published online Oct. 23, 2013;
Contact: Scott W. Lowe, Memorial Sloan-Kettering Cancer
New York, N.Y.
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]