Thursday, December 5, 2013
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Mouse model of intrahepatic
Orthotopic allograft mouse
models of ICC could be used to validate drivers of the disease. In mice,
intrahepatic implantation of mouse liver progenitor cells
expressing mutant forms of p53 and K-Ras (KRAS) caused development of
tumors with histological features of ICC, including stromal cell
infiltration. In the model, induced expression of a fusion gene
containing Golgi-associated PDZ and coiled-coil motif
containing (GOPC; FIG) linked to c-ros proto-oncogene 1 receptor tyrosine kinase (ROS1), which has been
found in a subset of patients with ICC, accelerated tumor growth. In the
mouse model with established tumors that expressed the fusion gene, turning
off its expression prevented further tumor growth. Next steps could
include using the model to validate additional ICC targets.
Published online Dec. 5, 2013
Patent and licensing status
Saborowski, A. et
al. Proc. Natl. Acad. Sci. USA; published online Oct. 23, 2013;
Contact: Scott W. Lowe, Memorial Sloan-Kettering Cancer
New York, N.Y.
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