Thursday, November 21, 2013
This week in techniques
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A vaccine based on a
stabilized variant of respiratory syncytial virus (RSV) F protein
A stabilized variant of RSV F
protein could be used as a vaccine antigen to prevent RSV
infection. RSV F was modified with C-terminal trimerization domains, cysteine
pairs and cavity-filling hydrophobic substitutions to generate stable RSV F
trimers that resembled a conformation of the protein adopted before
virus-cell interaction. In mice, vaccination with modified RSV F provided
neutralizing activity eight times greater than that achieved with vaccination
using an RSV F antigen that adopted a conformation seen after virus-cell
fusion. In rhesus macaques, vaccination with the modified RSV F provided
neutralizing activity 70-80 times greater than that seen with vaccination
using the postfusion-like RSV F.
Next steps include moving the modified version of RSV F into GMP production
for clinical trials.
At least nine companies have therapeutics or vaccines in development to treat
Published online Nov. 21, 2013
RSV F glycoproteins as vaccine antigens are patented; available for licensing
through the NIH's
Office of the Director
McLellan, J.S. et al.
published online Nov. 1, 2013;
Contact: Peter D. Kwong, National Institutes of Health, Bethesda,
Contact: Barney S. Graham,
same affiliation as above
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