This week in techniques



Licensing status

Publication and contact information

Drug platforms

A vaccine based on a stabilized variant of respiratory syncytial virus (RSV) F protein

A stabilized variant of RSV F protein could be used as a vaccine antigen to prevent RSV infection. RSV F was modified with C-terminal trimerization domains, cysteine pairs and cavity-filling hydrophobic substitutions to generate stable RSV F trimers that resembled a conformation of the protein adopted before virus-cell interaction. In mice, vaccination with modified RSV F provided neutralizing activity eight times greater than that achieved with vaccination using an RSV F antigen that adopted a conformation seen after virus-cell fusion. In rhesus macaques, vaccination with the modified RSV F provided neutralizing activity 70-80 times greater than that seen with vaccination using the postfusion-like RSV F.
Next steps include moving the modified version of RSV F into GMP production for clinical trials.
At least nine companies have therapeutics or vaccines in development to treat RSV.

SciBX 6(45); doi:10.1038/scibx.2013.1304
Published online Nov. 21, 2013

The prefusion-stabilized RSV F glycoproteins as vaccine antigens are patented; available for licensing through the NIH's Office of the Director

McLellan, J.S. et al. Science;
published online Nov. 1, 2013;
Contact: Peter D. Kwong, National Institutes of Health, Bethesda, Md.
Contact: Barney S. Graham,
same affiliation as above