Thursday, November 7, 2013
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transcriptional activation using DNA
DNMT1-mediated gene methylation using gene-specific RNAs could provide a
mechanism for activating gene expression. A DNMT1-binding, noncoding RNA
sequence was identified at the CCAAT enhancer binding protein-a
(CEBPA) gene that
suppressed local DNA methylation and increased CEBPA transcription. In
a genomewide survey, thousands of DNMT1-RNA interactions were discovered,
suggesting this could be a previously unknown, gene-specific activating
mechanism. Next steps include using clustered,
regularly interspaced short palindromic repeats (CRISPR)
technology to guide noncoding RNA-derived oligonucleotides to
disease-suppressing genes to increase their activation.
Published online Nov. 7, 2013
Patent applications filed;
available for licensing
Di Ruscio, A. et al.
Nature; published online Oct. 9, 2013;
Contact: Daniel G. Tenen, Harvard Medical School and Beth Israel
Deaconess Medical Center,
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