Thursday, October 31, 2013
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Gene expression signature
to predict outcome in patients with idiopathic pulmonary fibrosis (IPF)
Studies in patient samples
identified a gene expression signature that could help predict outcomes in
patients with IPF. In peripheral blood mononuclear cells (PBMCs) from 45
patients with IPF, microarray analysis identified 7 genes whose high
expression was associated with shorter transplant-free survival and 45 genes
whose low expression was associated with shorter transplant-free survival. In
a replication cohort of 75 patients, cluster analysis based on the 52-gene
signature showed that a high-risk group had median transplant-free survival
of 1.62 years, whereas a low-risk group had a median of 3.44 years. In the
patient cohorts, quantitative RT-PCR analysis of 4 genes from the 52-gene
panel was sufficient to predict poor outcomes as measured by decreased
transplant-free survival. Next steps include validating the gene signature in
a larger patient cohort.
Published online Oct. 31, 2013
Patent application filed;
licensing details available from The University
of Chicago and the University
Herazo-Maya, J.D. et al.
Sci. Transl. Med.; published online Oct. 2, 2013;
Contact: Naftali Kaminski,
Yale School of Medicine, New Haven, Conn.
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