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Gene expression signature to predict outcome in patients with idiopathic pulmonary fibrosis (IPF)

Studies in patient samples identified a gene expression signature that could help predict outcomes in patients with IPF. In peripheral blood mononuclear cells (PBMCs) from 45 patients with IPF, microarray analysis identified 7 genes whose high expression was associated with shorter transplant-free survival and 45 genes whose low expression was associated with shorter transplant-free survival. In a replication cohort of 75 patients, cluster analysis based on the 52-gene signature showed that a high-risk group had median transplant-free survival of 1.62 years, whereas a low-risk group had a median of 3.44 years. In the patient cohorts, quantitative RT-PCR analysis of 4 genes from the 52-gene panel was sufficient to predict poor outcomes as measured by decreased transplant-free survival. Next steps include validating the gene signature in a larger patient cohort.

SciBX 6(42); doi:10.1038/scibx.2013.1209
Published online Oct. 31, 2013

Patent application filed; licensing details available from The University of Chicago and the University of Pittsburgh

Herazo-Maya, J.D. et al. Sci. Transl. Med.; published online Oct. 2, 2013;
Contact: Naftali Kaminski,
Yale School of Medicine, New Haven, Conn.