Thursday, October 31, 2013
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Reprogramming in vivo
to generate totipotent induced pluripotent stem (iPS) cells
In vivo reprogramming in mice could be used to generate
highly plastic iPS cells that can efficiently contribute to extraembryonic
tissue such as placenta. Mice were engineered to express four
doxycycline-inducible reprogramming factors: Oct4,
In these mice, doxycycline led to the formation of
iPS cells in multiple organs that originated from multiple cell types. The in
vivo-generated iPS cells were more efficient at forming embryonic and
extraembryonic tissues than embryonic stem cells or in vitro-generated
iPS cells. Next steps include understanding the mechanism of in vivo
reprogramming and why the resulting iPS cells show greater totipotency than
other stem cell lines.
Published online Oct. 31, 2013
Patent application filed;
available for licensing through the Botín
Contact: Miriam Zeini, Botín
Foundation, Madrid, Spain
Abad, M. et al. Nature;
published online Sept. 11, 2013;
Contact: Manuel Serrano, Spanish National Cancer Research
Centre (CNIO), Madrid, Spain
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