Approach

Summary

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Drug platforms

Intramyocardial injection of synthetic modified RNA (modRNA) encoding VEGF-A to expand and direct differentiation of cardiac progenitor cells

Mouse studies suggest pulse-like expression of VEGF-A from modRNA could help regenerate cardiac tissue. In a mouse model of myocardial infarction, modRNA- and DNA-mediated expression of VEGF-A increased capillary density and decreased apoptosis and infarct size compared with vehicle. In the model, modRNA-mediated expression of VEGF-A increased long-term survival compared with that seen using vehicle. In contrast, DNA-mediated expression of VEGF-A decreased short-term survival. Next steps include testing this approach in larger animal models and humans.

SciBX 6(42); doi:10.1038/scibx.2013.1205
Published online Oct. 31, 2013

Patented; available for licensing

Zangi, L. et al. Nat. Biotechnol.; published online Sept. 8, 2013;
doi:10.1038/nbt.2682
Contact: Kenneth R. Chien, Karolinska Institute, Stockholm, Sweden
e-mail:
kenneth.chien@ki.se