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Drug platforms

Image-based high-content screening platform to survey large compound libraries

A platform combining chemical screening with automated image acquisition and analysis could enable the identification of compounds that inhibit disease-associated signal transduction pathways. To demonstrate proof of concept for the approach, about 17,000 compounds were screened for their potential to interfere with the subcellular localization of a fluorescent Notch 1 (NOTCH1) reporter. The screen led to the isolation of two new g-secretase inhibitors and FLI-06, a dihydropyridine that decreased protein trafficking. Next steps include applying the platform to other signaling pathways and further developing FLI-06.

SciBX 6(42); doi:10.1038/scibx.2013.1204
Published online Oct. 31, 2013

Patent filed covering use of FLI-06 and derivatives; not yet available for licensing

Krämer, A. et al. Nat. Chem. Biol.; published online Sept. 29, 2013;
Contact: Christoph Kaether,
Fritz Lipmann Institute, Jena, Germany