Thursday, October 31, 2013
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screening platform to survey large compound libraries
A platform combining
chemical screening with automated image acquisition and analysis could enable
the identification of compounds that inhibit disease-associated signal
transduction pathways. To demonstrate proof of concept for the approach,
about 17,000 compounds were screened for their potential to interfere with
the subcellular localization of a fluorescent Notch 1
reporter. The screen led to the isolation of two new g-secretase inhibitors and FLI-06,
that decreased protein trafficking. Next steps include applying the platform
to other signaling pathways and further developing FLI-06.
Published online Oct. 31, 2013
Patent filed covering use
of FLI-06 and derivatives; not yet available for licensing
Krämer, A. et al. Nat.
Chem. Biol.; published online Sept. 29, 2013;
Contact: Christoph Kaether,
Fritz Lipmann Institute, Jena, Germany
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