Thursday, October 31, 2013
Publication and contact
screening platform to survey large compound libraries
A platform combining
chemical screening with automated image acquisition and analysis could enable
the identification of compounds that inhibit disease-associated signal
transduction pathways. To demonstrate proof of concept for the approach,
about 17,000 compounds were screened for their potential to interfere with
the subcellular localization of a fluorescent Notch 1
reporter. The screen led to the isolation of two new g-secretase inhibitors and FLI-06,
that decreased protein trafficking. Next steps include applying the platform
to other signaling pathways and further developing FLI-06.
Published online Oct. 31, 2013
Patent filed covering use
of FLI-06 and derivatives; not yet available for licensing
Krämer, A. et al. Nat.
Chem. Biol.; published online Sept. 29, 2013;
Contact: Christoph Kaether,
Fritz Lipmann Institute, Jena, Germany
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]