Licensing status

Publication and contact information

Drug delivery

DNA nanostructures for targeted drug delivery

Nanostructures generated via unconventional assembly of DNA could enable targeted drug delivery or be used as imaging agents. Rolling circle replication and liquid crystallization of long DNA building blocks created stable structures called nanoflowers that did not rely on Watson-Crick base pairing. These structures resisted denaturation, dissociation at low concentrations and degradation by DNase 1 in human serum. In flow cytometry studies, aptamer-loaded complexes showed greater colocalization with cancer cells than with control cells. In cancer cell lines, doxorubicin-containing aptamer nanoflowers showed increased cytotoxicity compared with free doxorubicin. Next steps include process optimization and preclinical pharmacokinetic testing of the nanoflowers.

SciBX 6(42); doi:10.1038/scibx.2013.1202
Published online Oct. 31, 2013

Patent filed by the University of Florida; available for licensing

Zhu, G. et al. J. Am. Chem. Soc.; published online Sept. 18, 2013;
Contact: Weihong Tan, University of Florida, Gainesville, Fla.