Thursday, October 31, 2013
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DNA nanostructures for
targeted drug delivery
via unconventional assembly of DNA could enable targeted drug delivery or be
used as imaging agents. Rolling circle replication and liquid crystallization
of long DNA building blocks created stable structures called nanoflowers that
did not rely on Watson-Crick base pairing. These structures resisted
denaturation, dissociation at low concentrations and degradation by DNase 1 in
human serum. In flow cytometry studies, aptamer-loaded complexes showed
greater colocalization with cancer cells than with control cells. In cancer
cell lines, doxorubicin-containing aptamer nanoflowers showed
increased cytotoxicity compared with free doxorubicin. Next steps include
process optimization and preclinical pharmacokinetic testing of the
Published online Oct. 31, 2013
Patent filed by the University of Florida; available
Zhu, G. et al. J. Am.
Chem. Soc.; published online Sept. 18, 2013;
Contact: Weihong Tan, University of Florida, Gainesville, Fla.
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