Thursday, October 24, 2013
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Major histocompatibility complex class I (MHC)-associated
phosphopeptides to predict clinical outcome in leukemia
phosphopeptides recognized by MHC could help predict outcomes for patients
with leukemia. The phosphopeptide repertoires from 11 tumor samples
representing multiple leukemia types were profiled for binding to MHC
molecules. In samples from patients with leukemia, immune responses to the
MHC-binding phosphopeptides were decreased compared with those of healthy
donors. Patients without immune responses to the phosphopeptides had
decreased survival compared with those who showed immune responses to the
phosphopeptides. Next steps include developing phosphopeptide antigens for
Inc. is developing therapeutics and diagnostics related to
Published online Oct. 24, 2013
Patented; licensed to
PhosImmune, a company spun-out of the University
of Virginia School of Medicine
Cobbold, M. et al. Sci.
Transl. Med.; published online Sept. 13, 2013;
Contact: Victor H. Engelhard, University of Virginia,
Contact: Mark Cobbold, University of Birmingham, Birmingham,
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