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Disease models

A mouse model of schizophrenia involving disruption of GABAA receptor clustering

Mice with disrupted clustering of GABAA receptors could provide a model of schizophrenia. In mice, infection with a virus (AAV-DN1) encoding a dominant-negative GABAA receptor-based fusion protein decreased the clustering of GABAA receptor a2 (Gabra2) subunits compared with infection using a control virus. In behavioral studies in mice, AAV-DN1 decreased prepulse inhibition and working memory function compared with control virus. In electroencephalogram studies in mice, AAV-DN1 decreased g-frequency rhythmic brain activity compared with control virus. Next steps include testing modulators of GABRA2 subunits to reverse schizophrenia-like behavior in the mouse model.

SciBX 6(41); doi:10.1038/scibx.2013.1169
Published online Oct. 24, 2013

Patent application filed by Tufts University; licensing status unavailable

Hines, R.M. et al. Proc. Natl. Acad. Sci. USA; published online Sept. 16, 2013;
Contact: Stephen J. Moss, Tufts University, Boston, Mass.