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Kaposi sarcoma-associated herpes virus (KSHV; HHV-8) as a biomarker for castration-resistant prostate cancer (CRPC)

Cell-based studies suggest KSHV infection might serve as a marker for CRPC. In androgen-insensitive prostate cancer cell lines, KSHV infection increased proliferation and anchorage-independent cell growth compared with no infection. In androgen-sensitive prostate cancer cells, KSHV infection increased androgen-independent growth and epithelial-to-mesenchymal transition (EMT) compared with no infection. Next steps include exploring mechanisms of KSHV-induced EMT as markers of disease metastasis and treatment resistance.

SciBX 6(40); doi:10.1038/scibx.2013.1149
Published online Oct. 17, 2013

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Mygatt, J.G. et al. Cancer Res.; published online Sept. 4, 2013;
Contact: Johnan A.R. Kaleeba, Uniformed Services University of the Health Sciences, Bethesda, Md.