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2-Aminoadipic acid as a predictive marker for type 2 diabetes

A study in humans suggests measuring concentrations of 2-aminoadipic acid in blood could help predict the risk of developing type 2 diabetes. A retrospective analysis of 70 metabolites measured in the blood of 350 patients with type 2 diabetes and 350 controls at risk of developing the disease showed that elevated 2-aminoadipic acid levels correlated with a diagnosis of type 2 diabetes 12 years later (p<0.0001). Next steps include prospective studies examining the relationship between 2-aminoadipic acid, disease progression and response to type 2 diabetes therapies.

SciBX 6(40); doi:10.1038/scibx.2013.1148
Published online Oct. 17, 2013

Patent pending; available for licensing

Wang, T.J. et al. J. Clin. Invest.; published online Sept. 16, 2013;
Contact: Robert E. Gerszten, Massachusetts General Hospital, Charlestown, Mass.
Contact: Thomas J. Wang, Vanderbilt University Medical Center,
Nashville, Tenn.