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Drug delivery

Tumor-specific delivery of chemotherapy using micelles with phenylboronic acid on their surface

Polymeric PBA-micelles could enable tumor-specific delivery of chemotherapy. PBA has a high binding affinity for sialic acids, which are highly expressed on cancer cells but not normal cells. In a mouse melanoma cell line, PBA-micelles loaded with oxaliplatin exhibited greater uptake and cytotoxicity and longer intracellular retention times than free oxaliplatin or oxaliplatin-loaded micelles lacking PBA. In a mouse model of melanoma, oxaliplatin-loaded PBA-micelles had greater accumulation in primary tumors and lung metastases and decreased tumor growth compared with free oxaliplatin or oxaliplatin-loaded micelles lacking PBA. Future studies could include generating and testing PBA-micelles loaded with other chemotherapeutics.

SciBX 6(40); doi:10.1038/scibx.2013.1143
Published online Oct. 17, 2013

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Deshayes, S. et al. J. Am. Chem. Soc.; published online Sept. 12, 2013;
Contact: Kazunori Kataoka, The University of Tokyo, Tokyo, Japan