Thursday, October 10, 2013
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Stimulated Raman scattering
(SMS) microscopy for label-free imaging of tumor-infiltrated brain tissues
Mouse studies suggest SRS
microscopy could help detect tumor margins during brain cancer surgery
without using a molecular label. In mice with human glioblastoma multiforme
xenografts, SRS imaging was able to differentiate tumor tissue from normal
brain tissue ex vivo and during surgery and was comparable to
microscopy using the hematoxylin and eosin (H&E) stain. In brain samples
from patients with glioblastoma, SRS imaging results corresponded with tumor
margins identified with H&E staining. Next steps include developing a
clinical system for the technology and establishing safety and efficacy.
Published online Oct. 10, 2013
Findings patented; Leica Microsystems GmbH has
co-exclusive rights for research microscopy; Invenio Imaging Inc. has an
option for a co-exclusive research microscopy license and an exclusive
license in all other fields; unavailable for licensing
Ji, M. et al. Sci.
Transl. Med.; published online Sept. 4, 2013;
Contact: X. Sunney Xie, Harvard University, Cambridge, Mass.
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