Approach

Summary

Licensing status

Publication and contact information

Imaging

Stimulated Raman scattering (SMS) microscopy for label-free imaging of tumor-infiltrated brain tissues during surgery

Mouse studies suggest SRS microscopy could help detect tumor margins during brain cancer surgery without using a molecular label. In mice with human glioblastoma multiforme xenografts, SRS imaging was able to differentiate tumor tissue from normal brain tissue ex vivo and during surgery and was comparable to microscopy using the hematoxylin and eosin (H&E) stain. In brain samples from patients with glioblastoma, SRS imaging results corresponded with tumor margins identified with H&E staining. Next steps include developing a clinical system for the technology and establishing safety and efficacy.

SciBX 6(39); doi:10.1038/scibx.2013.1116
Published online Oct. 10, 2013

Findings patented; Leica Microsystems GmbH has co-exclusive rights for research microscopy; Invenio Imaging Inc. has an option for a co-exclusive research microscopy license and an exclusive license in all other fields; unavailable for licensing

Ji, M. et al. Sci. Transl. Med.; published online Sept. 4, 2013;
doi:10.1126/scitranslmed.3005954
Contact: X. Sunney Xie, Harvard University, Cambridge, Mass.
e-mail:

xie@chemistry.harvard.edu