Thursday, October 10, 2013
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Integrated approach to
accelerate biomimetic material engineering
An integrated platform that
combines RNA-seq with standard proteomics and materials science approaches
could accelerate the development of new biomimetic materials. The platform
involves generating a transcriptome database for a tissue of interest using RNA-seq
and then using proteomics tools to identify the sequence and structure of
relevant proteins that have a desired function or property. The approach was
used to identify a shock-absorbing elastomer protein from the egg capsule of
a marine snail, an underwater adhesive protein from the byssal complex of a
mussel and a silk-like protein from squid sucker ring teeth. Recombinant
forms of the silk-like protein were generated and used to build surfaces and
films with elastic moduli and stiffness superior to those of many other
engineered polymers. Next steps include testing the engineered biomaterials
as scaffolds in cell and tissue cultures and evaluating their in vivo
biocompatibility and degradation rates.
Published online Oct. 10, 2013
Patent and licensing status
Guerette, P.A. et al.
Nat. Biotechnol.; published online Sept. 8, 2013;
Contact: Ali Miserez, Nanyang Technological University, Singapore
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