Thursday, October 10, 2013
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Web-based platform to
identify cancer driver mutations across tumor types based on new and existing
A computational model
called IntOGen-mutations could help to identify mutations that drive tumor
formation. The platform integrates sequencing data from tumor genomes and
genome analyzers to a scale of hundreds of thousands of genomes. The platform
predicts the functional impact of nonsynonymous somatic tumor mutations on
protein and pathway function. Next steps include updating the platform with
more somatic mutation datasets from tumor genomes and enriching it with data
on protein-drug interactions.
Published online Oct. 10, 2013
Unpatented; available for
licensing through the Pompeu Fabra University
Technology Transfer Office; platform accessible at http://www.gitools.org/datasets/
Gonzalez-Perez, A. et
al. Nat. Methods; published online
Sept. 15, 2013;
Contact: Nuria Lopez-Bigas, Pompeu Fabra University,
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