Thursday, October 10, 2013
Publication and contact
Assays & screens
profiling (BCP) to identify the mechanism of action for antibacterial
BCP can help identify the mechanism of action for antibacterial compounds.
BCP distinguished between inhibitors of five major biological pathways
including translation, transcription, DNA replication, membrane synthesis and
peptidoglycan synthesis. BCP also distinguished subclasses of inhibitors
within each of the five classes. In Escherichia coli grown in the
presence of compounds at five times minimum inhibitory concentration, BCP
revealed that spirohexenolide A-a compound with an
unknown mechanism of action-caused a collapse in proton motive force and
induced a phenotype similar to that initiated by the antibacterial peptide nisin.
Next steps include using BCP to screen for new antibacterial compounds and
developing BCP for use in other pathogens.
Published online Oct. 10, 2013
Patent application filed;
licensed to Linnaeus Bioscience Inc.
Nonejuie, P. et al.
Proc. Natl. Acad. Sci. USA; published online
Sept. 17, 2013;
Contact: Joe Pogliano, University of California, San Diego,
La Jolla, Calif.
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