Thursday, October 3, 2013
Publication and contact
Secondary Cherenkov-induced fluorescence imaging (SCIFI) to detect markers of disease
Mouse studies suggest SCIFI
could help detect and monitor markers of disease activity. SCIFI relies on
the interaction between radionuclides and fluorescent nanoparticles, which
generates secondary Cherenkov fluorescent signals that can be detected by
their signal-to-noise ratios, which are greater than those produced by
conventional fluorescent imaging. In mice with breast cancer xenografts,
SCIFI selectively and noninvasively visualized tumors bound by both a
radiolabeled HER2 (EGFR2; ErbB2; neu) mAb and an integrin aVb3
fluorescent quantum dot. In mice with matrix metalloproteinase 2
tumors, SCIFI visualized MMP2 activity at tumors by detecting the interaction
of 18F-labeled fluorodeoxyglucose with a fluorescent
nanoparticle activated by cleavage by MMP2. Next steps include toxicity
studies of potential imaging agents.
Published online Oct. 3, 2013
unavailable for licensing
Thorek, D.L.J. et al.
Nat. Med.; published online Sept. 8, 2013;
Contact: Jan Grimm, Memorial Sloan-Kettering Cancer Center,
New York, N.Y.
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]