Thursday, October 3, 2013
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Secondary Cherenkov-induced fluorescence imaging (SCIFI) to detect markers of disease
Mouse studies suggest SCIFI
could help detect and monitor markers of disease activity. SCIFI relies on
the interaction between radionuclides and fluorescent nanoparticles, which
generates secondary Cherenkov fluorescent signals that can be detected by
their signal-to-noise ratios, which are greater than those produced by
conventional fluorescent imaging. In mice with breast cancer xenografts,
SCIFI selectively and noninvasively visualized tumors bound by both a
radiolabeled HER2 (EGFR2; ErbB2; neu) mAb and an integrin aVb3
fluorescent quantum dot. In mice with matrix metalloproteinase 2
tumors, SCIFI visualized MMP2 activity at tumors by detecting the interaction
of 18F-labeled fluorodeoxyglucose with a fluorescent
nanoparticle activated by cleavage by MMP2. Next steps include toxicity
studies of potential imaging agents.
Published online Oct. 3, 2013
unavailable for licensing
Thorek, D.L.J. et al.
Nat. Med.; published online Sept. 8, 2013;
Contact: Jan Grimm, Memorial Sloan-Kettering Cancer Center,
New York, N.Y.
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